Smosh Lab is a show on Smosh Pit (formerly Smosh 2nd Channel) created for Smoshtober. It premiered on October 5, 2016 with the episode Smashing Stuff with Science! and stars Shayne Topp together with Nick Uhas from Nickipedia as hosts. In every episode, the pair of Topp and Uhas recreate different science experiments by themselves or sometimes with invited guests.
Even though it was supposedly created for Smoshtober, Shayne stated in the comments that if people like it enough it could continue afterwards.
In the first Smoshcast, HOW SMOSH BEAT DEFY, Shayne and Courtney both talk about their respective shows on Defy-era Smosh. Shayne recounts executives coming to him with the order that he must create a 'science show', and be the 'science one' of the squad. This order would later become Smosh Lab. Though the show wasn't something they wanted to do, and was definitely just a push from Defy to diversify their content for both advertisers and perspective viewers, Shayne said that he did enjoy doing the show in the long run.