Outside of Smosh Games, Operation has been played on Smosh is Bored in SHOCKING OPERATION and in The Show w/ No Name! episode OPERATION FAIL. It was also featured in the Smosh sketch IF BOARD GAMES WERE REAL.
Operation includes two sets of cards: The Specialist cards are dealt out evenly amongst the players at the beginning of the game.
In the U.S and Australian version, players take turns picking Doctor cards, which offer a cash payment for removing each particular ailment, using a pair of tweezers connected with wire to the board. Successfully removing the ailment is rewarded according to the dollar amount shown on the card. However, if the tweezers touch the metal edge of the opening during the attempt (thereby closing a circuit), a buzzer sounds, Sam's nose lights up red, and the player loses the turn. The player holding the Specialist card for that piece then has a try, getting double the fee if he or she succeeds.
Since there will be times when the player drawing a certain Doctor card also holds the matching Specialist card, that player can purposely botch the first attempt in order to attempt a second try for double value.
The winner is the player who holds the most money after all the ailments are extracted.
The game can be difficult, due to the shapes of the plastic ailments and the fact the openings are barely larger than the pieces themselves.
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