- Grandson: "Ah! Nana! You're naked again!"
- Nana Mongeau: "Aw, give me a hug! This is gonna be an amazing thumbnail!"
- — Nana Mongeau flashing her grandsons for clickbait
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- Courtney Miller as Nana Mongeau, Jeffree Star, Tati Westbrook, and herself
- Damien Haas as Nana Mongeau's grandson, Shane Dawson, Sean Evans, and himself
- Shayne Topp as Nana Mongeau's grandson, Gordon Ramsay and himself
- Rhett McLaughlin and Link Neal of Rhett and Link as themselves
- Olivia Sui as Safiya Nygaard and herself
- Gus Johnson as himself
- Keith Leak Jr. as himself
- Noah Grossman as Cashier and James Charles
- Director: Ryan Todd
- 1st Assistant Director: David Gutel
- Writers: Monica Vasandani, Damien Haas, Shayne Topp, Courtney Miller, Ian Hecox and Ryan Finnerty
- Script Supervisor: Eddie Vigil V
- Production Manager: Margo McHugh
- Production Assistant: Jacqi Jones
- Executive Producer: Ryan Todd
- Director of Photography: Mitch Anderson
- Camera Operator: Brennan Iketani
- Digital Imaging Technician: Matt Duran
- Art Director/Costumes: Steven Cirocco
- Set Decorator: Tayler Nicholson
- Props/Stage Coordinator: Yasmeen Mughal
- Community Manager: Cece Wrenn
- Content Manager: Kiana Parker
- IT/Equipment Manager: Tim Baker
- Executive Assistant: Nancy Azcona
- Editor: Mike Small
- GFX: Brittany Metz
- Wardrobe: Meredeth Peebles
- Sound: Greg Jones
- Gaffer: Billy Yates
- Key Grip: Nick Giomuso
- Grip: Angelique A. Costanza
- Makeup: Rachel Jenkins and Brooke Darwin
- Buyer: Natalia Brito
- Carpenter: Phil Huertas
Tana Mongeau/Nana Mongeau
Nana Mongeau is in the process of filming another video, talking about how she is "f*cked up on blood thinners" and how her grandchildren are coming to visit. At that moment, her two grandsons (Shayne and Damien) walk in and greet her. Nana stands up to meet them, flashing her grandsons and inviting them to give her a hug, much to their disgust. Nana looks back at the camera with an eager face, knowing that the shot will make an "amazing" thumbnail.
"Barkiplier" is portrayed as a dog with headphones, with voiceover done in a comically deep voice that greets the viewers, imitates dog noises, and expresses a desire to cry.
Rhett & Link/Rhett & Kink
On an episode of Good Mythical Morning, Rhett and Link prepare to compare cheese and expired milk right before the show would cut to the opening sequence. Link sneaks in a mention his foot fetish, causing Rhett to look at him in alarm.
Jeffree Star/Jeffree Stab
Jeffree stabs a co-star (Damien). As he slumps to the ground, she shakes a bottle of perfume and sprays it on his face.
Gus Johnson/Bus Johnson
Gus imitates a bus, stopping at a bus stop with Courtney on his back and picks up Olivia. He walks away, making engine noises with his mouth. A late Shayne runs after them.
Gus Johnson/Gun Johnson
Olivia is at a gas station when a crook walks up to her and demands her purse. He pulls out Gus, carrying the comedian's body like a two-handed firearm, shooting bullets around Olivia (while Gus shouts "Bang! Bang! Bang!").
Gus Johnson/Us Johnson
Based on the 2019 horror film Us, Gus encounters his doppelganger. Gus gives his doppelganger tips on how to deliver a creepy performance.
Safiya Nygaard/Safiya Nyguard
Keith is looking for some NyQuil and the store clerk points him to it, but warns that he will need to get through "her" first. The camera turns to show Safiya Nygaard holding a sword and shield in an aggressive stance, guarding the "Cold & Flu Medicine" section, and challenges Keith to try. Keith looks back at the clerk, who only shrugs.
Hot Ones/Hat Ones
Sean Evans is interviewing Gordon Ramsay while the two wear silly hats. Gordon is trying to concentrate on the interview but is increasingly distracted by the silliness of each new hat. Gordon eventually gives up and demands to be allowed to leave.
Lele Pons/Lele Pond
Shayne admires a pond aloud. Lele Pons corrects him, stating that she is Latina.
James Charles/James Charges
James charges a series of electronic devices, including an iPhone, wireless headphones, a MacBook, and a purple vibrator. The scene switches to a parody of Tati Westbrook's video "BYE SISTER...", in which she describes her disgust at James over how he uses his fame, wealth, and power to charge other devices when she has devices that need charging.
- Link describes his foot fetish to an amused Rhett as the two list what types of feet they enjoy.
- Courtney "stabs" Damien a bit too sharply.
- Rhett and Link continue listing what types of feet they enjoy.
- Olivia pretends to be riddled with bullets, causing her blonde wig to fall off.
- Link mentions wikifeet.com, a foot fetish website he often goes on. Rhett mentions that he has shown it to him a few times before.
- Damien and Shayne talk about how silly they look in silly hats.
- ↑ @smosh on Twitter: "One letter off Youtubers. NEW SKETCH TOMORROW. It's spicy. / Smack that Notification Bell so hard: https://smo.sh/Sub2Smosh / 📸 by @BIketani"
- ↑ Smosh on Instagram: "One letter off Youtubers. NEW SKETCH TOMORROW. It's spicy. / Smack that Notification Bell so hard! 📸 by @b.iketani"
- ↑ noahgrossman214 on Instagram: "Sisters!!! 💄💋👯♂️👑 -- On the real though, @co_mill spent like 35 minutes making me @jamescharles ,and I didn’t even have a line 😂 - Makeup is fun 🤷🏼♂️ - #JamesCharles #makeupartist #Comedy #smosh #noahgrossman"
- ↑ damienhaas on Instagram: "Show pitch: Hat Ones. 10 levels of hat, increasing in difficulty as you go."